Botulinum toxin represents a gold standard in dealing with wrinkles on the forehead and around the eyes.

Botulinum toxin is a natural purified protein produced by the bacteria Clostidium botulinum, which blocks overemphasized nerve impulses, and by that, excessive, uncontrolled muscle contractions.

The area of its used was, thus, ophthalmology, neurology, pediatrics – for lessening of the excessive blinking, facial paresis or blepharospasm. As a coincidental side-effect, it was noticed that it ‘wipes away’ wrinkles on the forehead. It used to be called ‘the most wanted poison in the world’.

After a series of clinical trials and studies, starting in the 90s, Botulinum toxin started to be used in medicine for esthetic purposes as well, in plastic surgery.

It is relevant to point out that the treatment was in 2002 approved by the American organization Food and Drug Administration (FDA) that controls quality and safety of food and medications. Research has shown that only in the USA, after the approval, more than one million people have opted for a Botulinum toxin treatment.

Description of the procedure

Botulinum toxin treatment is safe and is one of the most effective and most popular esthetic treatments for removal of wrinkles in the area of forehead and laugh lines. Botulinum toxin treatment is a simple, non-invasive procedure performed by a doctor. It is performed in such way that the preparation is carefully and precisely injected under the skin in places where wrinkles need to be removed or reduced. By doing so, certain muscles that are a part of facial mimics are blocked, which reduces or removes wrinkles. The activity of the preparation is localized only to spots where it was injected.
The procedure is simple and lasts for only a couple of minutes. The preparation is injected using very thin needles, so it is painless and does not leave hematoma.
The result of the procedure, as well as with some other similar esthetic treatments, is not permanent because a substance which could stop aging has not yet been discovered.

Two dosages are offered:
Botulinum toxin – consists of 100 units.
Vistabel – known as ‘Baby Botulinum toxin’, has 50 units. Baby Botulinum toxin treatments contain minimum doses of Botulinum toxin applied to common areas. The results are very similar to normal dosage, but still, they allow greater mobility of the face. Given that the period of its duration is shorter, it is recommended to repeat the treatment after 3-4 months.


Donedavno, na pomlađivanje Botulinum toxinom odlučivale su se osobe zrele dobi, od 40. godine naviše; sada se stavovi mijenjaju te se na ‘brisanje’ bora odlučuje sve više 30-godišnjaka.
Botulinum toxin ima odobrenje za uspješno tretiranje izraženih horizontalnih bora na čelu i okomitih između obrva te tzv. bora smijalica u kutovima očiju.
Tretman se ne smije izvoditi ako postoji infekcija (akne, impetigo, herpes..) na mjestima na koja bi se preparat trebalo injicirati. Također, ne smije se izvoditi na pacijentima koji su osjetljivi odnosno alergični na bilo koji sastojak preparata.
Pacijenti s pojedinim neurološkim poremećajima (ALS, Myasthenia Gravis ili Lambert-Eaton sindrom) imaju povećan rizik pojave ozbiljnijih nuspojava.


After reviewing the facial muscles, a doctor will decide in which areas the preparation should be precisely injected. It requires an in-depth insight into the layout and structure of the facial muscles because they may significantly vary among people. Many inadequately trained doctors ignore this fact and therefore their results are not satisfactory.
Before the treatment, tell the doctor if you are breast-feeding, if you are planning to become pregnant, or if you are suffering from diseases.
Applying anesthetic cream at the area of treatment is possible with highly sensitive clients.

Course of the procedure

Botulinum toxin is carefully and precisely applied in very small quantity in the certain spots on the face of the patient. It blocks the work of particular muscles involved in facial mimics. This will reduce and remove wrinkles on the face, caused by strong activity of these muscles. The application itself is almost painless because it uses very thin needles. Places that are commonly treated are wrinkles on the forehead, fine lines on the outside of the eyes, and sometimes, wrinkles above the upper lip, wrinkles from the lip angle to the chin, bumps on the chin and wrinkles on the neck.
The effect is visible after a few days, usually 2-7. The existing facial wrinkles are gradually ‘erased’. In fact, natural exfoliation – peeling – of the epidermis, wrinkles become more shallow, and even disappear completely, depending on the depth and intensity. The process of exfoliation can be accelerated with additional microdermabrasion with (see below).

The durability of the final results of the procedure varies, according to the individual characteristics; in most cases about 4-6 months. The treatment can be repeated time and time again because it is not harmful for the health of the patient. It is only required that, between treatments, there is an appropriate time interval, which is determined by the doctor. Repetition of the treatment maintains a youthful and fresh look. It is important to mention that with repeated treatments the aesthetic effect of rejuvenation is more permanent.


The patient can return to his daily routine immediately after the procedure. Small bruising, which can be covered with powder, may occur where the injection was given. It is recommended that you remain in upright position for the next hour and avoid physical strain during the next 24 hours.
Botulinum toxin develops it full effect 2-7 days after the injection; it usually lasts 4-6-8 months.

Side effects and complications

Side-effects are very rare; some of them are strong headache, mild flu syndrome, temporary lowering of the eyelids and dizziness. Less frequently, there is facial pain, erythema at the injection spot and weakened muscles. All phenomena are associated with the injection because they occur during the first week after the procedure. All side effects are temporary and do not last more than a few days.


Package in Polyclinic Lege Artis includes the price of the preparation itself, prearrangement and the treatment itself, and, if necessary, control examination after 2 weeks. In cooperation with banks, Polyclinic Lege Artis provides debit card payment, one-time or in interest-free installments.

Book an appointment, consultation or intervention by calling +385 (0) 31 325 676

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